Liquid. Bioavailable.
Clinically-Backed
Methylfolate Benefits.

We take testing to another level because restoring your neurochemistry requires absolute precision.

We take L-Methylfolate science to another level because
restoring your neurochemistry requires absolute precision.

Liquid. Bioavailable.
Clinically-Backed.

We take L-Methylfolate science to another level because restoring your neurochemistry requires absolute precision.

We take testing to another level because restoring your
neurochemistry requires absolute precision.

Our Methylfolate Research Findings

Bioavailability & Cognitive Function

Optimized Methylfolate is clinically shown to bypass common gene mutations to fuel brain health.1-4

Up to 50% of the population has the MTHFR gene mutation, limiting their ability to convert standard folic acid into a usable form. Our Methylfolate is pre-methylated, ensuring it crosses the blood-brain barrier to support neurotransmitter synthesis and provide other Methylfolate benefits effectively.

Standard
Folic Acid
Diet + Standard
34%
of folate requirements utilized by brain
Optimized
Methylfolate
Diet + Methylfolate
92%
of folate requirements utilized by brain
ADDITIONAL INFO

What this means

Standard folic acid has to be converted into 5-MTHF (Methylfolate) before your body can use it. If you have the MTHFR mutation, that conversion is slowed or blocked, so folate never reaches the brain the way it should—even if you're taking supplements. Methylfolate is already in the active form, so it bypasses that entire bottleneck and goes straight to work.

Bioavailability

According to Methylfolate research, key nutrients in Neupril have been shown to be quickly and easily absorbed into the body.1

Placebo
Neupril Methyl-B12
ADDITIONAL INFO

What this means

Bioavailability refers to how easily your body can absorb and use a nutrient. When a vitamin is bioavailable, it means it can actually reach your bloodstream and support the processes it's meant to help. Dosage, formulation, and your own biology all influence how well this happens. Many methylfolate supplements rely on forms of nutrients that your body struggles to convert or absorb, limiting any real effect. Neupril uses methylated, ready-to-use B-vitamins that are designed for optimal bioavailability, giving your body direct access to Methylfolate benefits through an active form it needs for focus, energy, and emotional balance.

Nutrient Levels

Neupril Methyl-B12 improves key nutrient levels within 3 months.1

33%

increase in Vitamin B12 levels1

Placebo
Neupril Methyl-B12
VITAMIN B12 (PG/ML)
1. Based on a 12-week double-blind, placebo-controlled study of 45 participants supplementing with 1000mcg Methylcobalamin daily. Individual results may vary.
ADDITIONAL INFO

What this means

Methylcobalamin is the naturally occurring form of vitamin B12 that your body can use immediately. Clinical studies based on Methylfolate science show that consistent supplementation supports energy metabolism and nervous system health more effectively than synthetic alternatives.

Cellular Energy

Neupril Methylfolate is clinically shown to boost ATP production.1-3

Unlike standard folic acid, Neupril bypasses the MTHFR gene mutation, directly fueling the methylation cycle needed for mitochondrial efficiency.

Over 10x

Average increase in mitochondrial efficiency and ATP synthesis1-3

Control Neupril Methylfolate
ATP Energy Molecule
Inactive Mitochondria
Active Mitochondria
Cellular Waste
ADDITIONAL INFO

What this means

By providing L-5-MTHF directly, Neupril delivers Methylfolate benefits while eliminating the rate-limiting enzyme step. This allows for rapid synthesis of SAMe (S-adenosylmethionine), a universal methyl donor that stabilizes mitochondrial membranes and enhances electron transport chain function, resulting in a measurable surge in Adenosine Triphosphate (ATP) output.

A microscopic close-up image of red particles

Third Party Tested

Besides being backed by sound L-Methylfolate science, Neupril L-Methylfolate Drops are routinely third-party tested to verify potency, purity, and safety, ensuring every bottle matches the exact levels listed on the label.

Each batch is screened for vitamins, minerals, and potential contaminants so you can experience Methylfolate benefits while knowing exactly what you’re putting in your body.

Our drops are free from:

Pesticides

Heavy metals

Environmental contaminants

Microbial contaminants.

Red powder in a dish

Certifications

Neupril is manufactured in NSF, GMP-certified, and FDA-registered facilities in the United States. We prioritize high standards at every step, from sourcing to bottling, to ensure consistent quality you can trust.

Neupril L-Methylfolate + Methyl-B12 adult and kids liquid drops beside fresh berries on a clean studio background.

Free of Allergens

We don’t use wheat, dairy, egg, or peanut ingredients in our formula. Our manufacturing facilities follow strict allergen controls and validated cleaning protocols to minimize any chance of cross-contamination. We test for common allergens:

Gluten (Wheat, Rye, Barley)

Milk

Egg

Peanut

Neupril L-Methylfolate + Methyl-B12 adult and kids liquid drops beside fresh berries on a clean studio background.

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Neupril Pure Methylfolate

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Neupril Kids Methylfolate

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