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Neupril Pure Methylfolate

Neupril Pure Methylfolate

5-MTHF + B12 Complex

Supports methylation & brain health

Clears brain fog & reduces fatigue

Boosts focus, clarity, & sustained energy

Promotes balanced stress response

Nourishes healthy skin & stronger hair

Active folate and B12

30-day guarantee

Why Neupril?

It's Simple!

Neupril Pure Methylfolate gives you the active form of folate your body can readily use. This is especially important if you have an MTHFR gene variant.

Comprehensive: L-Methylfolate is the bioactive form of folate, supporting mood, focus, energy, and overall neurological health, without the conversion issues linked to MTHFR.

Delicious: A smooth berry liquid that makes daily nutrition an easy habit you'll want to keep.

Portable: Designed to fit your lifestyle, whether at work, home, or on the go. Just measure and take.

No Mess, No Stress: Forget the pills and chalky powders. One liquid solution for simple, effective nutrition.

Ingredients & Allergies

Ingredients

Neupril features a precise blend of ultra-high-potency, bioactive nutrients including 15 mg of L-Methylfolate (as L-5-Methylfolate, calcium salt) and 1000 mcg of Vitamin B12 (as Methylcobalamin) per serving. These active forms are specifically chosen for their superior bioavailability, ensuring you receive the most effective nutritional support for neurological health, cognitive function, and cellular energy.

Our liquid formula is crafted with clean, simple, and organic ingredients. The base consists of Reverse Osmosis Water and Organic Vegetable Glycerin, which acts as a natural, plant-based stabilizer. To ensure a pleasant experience, we use an Organic Berry Flavor system derived from Organic Acacia Gum and natural flavors, balanced with Citric Acid for freshness.

Neupril is 100% vegan, gluten-free, soy-free, dairy-free, and non-GMO. We take pride in a "clean label" approach: No artificial ingredients, no preservatives, and no synthetic dyes or sweeteners.

Lastly, Neupril is a liquid-drop formulation designed for maximum absorption. By avoiding the pectin or gelatin bases found in gummies, we deliver pure nutrients directly either under the tongue or easily added to water, juice, or your favorite smoothie.

Allergies

Neupril is entirely plant-based and vegan. These drops are free from gluten, dairy, soy, and nuts. Formulated without synthetic sweeteners, artificial additives, or synthetic dyes, it is a pure choice for sensitive systems.

Science & Certifications

Clinically Tested

Neupril is built on science and formulated with ingredients supported by decades of clinical research. This advanced adult supplement with methylfolate is designed for real absorption and impact, helping you get exactly what you need to function clearly and feel balanced. With a high-potency dose of 15 mg L-Methylfolate and 1000 mcg of Methyl B12, it is not just about convenience. It's about effectiveness you can truly feel.

Third-Party Testing

Every batch of Neupril undergoes rigorous third-party testing to ensure safety, potency, and label accuracy. We test for heavy metals, microbial contaminants, and ingredient integrity so you can feel confident about what you are putting in your body. Neupril is synonymous with methylated B12 and methylfolate, which is clean, effective, and transparent. Our "clean label" approach ensures that every 0.5 ml serving is free from artificial ingredients and preservatives.

Certifications

Neupril is manufactured in NSF, GMP-certified, and FDA-registered facilities in the United States. We prioritize high standards at every step, from sourcing our bioactive L-5-Methylfolate and Methylcobalamin to final bottling, to ensure consistent quality you can trust.

Shipping & Returns

At Neupril, we focus on delivering the fastest and most efficient service possible so you can start your wellness journey without delay.

  • Processing: All orders are processed within 24-48 hours, excluding weekends and holidays.
  • US/AUS Orders: Typically arrive within 3-7 business days.
  • International Orders: Typically arrive within 8-15 business days. Please note that international transit times may vary and could be extended due to local customs processing.

We are committed to unmatched customer satisfaction. To ensure you can try our products with total peace of mind, Neupril offers a 30-day return policy for first-time customers.

If you are not completely satisfied with our methylated folate or any other product in your first Neupril order, you may exchange it or return it within 30 days of purchase. We want to ensure you find the perfect fit for your specific health and wellness goals.

Directions

Each bottle of Neupril provides ultra-high potency methylfolate and bioactive B12. Give the bottle a quick shake and take 10 droplets or .5ml once daily. These can be taken under the tongue or easily added to water, juice, or your favorite smoothie for a daily boost to cognitive clarity and energy.

Benefits

The benefits of Neupril Pure Methylfolate could fill a whole list. Try saying all of this in one breath: improved mood, sharper focus, relief from fatigue, MTHFR support, balanced neurotransmitter function, homocysteine regulation, cardiovascular health, emotional well-being, nerve function support, healthy skin and hair, cognitive longevity, better sleep, steady energy, stress resilience, and overall brain and body wellness.

View full details

VEGAN

BIOAVAILABLE FORM

THIRD-PARTY TESTED (FOR HEAVY METALS & MIRCOBES)

NON-GMO

NO ARTIFICIAL INGREDIENTS

VEGAN

BIOAVAILABLE FORM

THIRD-PARTY TESTED (FOR HEAVY METALS & MIRCOBES)

NON-GMO

NO ARTIFICIAL INGREDIENTS

VEGAN

BIOAVAILABLE FORM

THIRD-PARTY TESTED (FOR HEAVY METALS & MIRCOBES)

NON-GMO

NO ARTIFICIAL INGREDIENTS

VEGAN

BIOAVAILABLE FORM

THIRD-PARTY TESTED (FOR HEAVY METALS & MIRCOBES)

NON-GMO

NO ARTIFICIAL INGREDIENTS

VEGAN

BIOAVAILABLE FORM

THIRD-PARTY TESTED (FOR HEAVY METALS & MIRCOBES)

NON-GMO

NO ARTIFICIAL INGREDIENTS

VEGAN

BIOAVAILABLE FORM

THIRD-PARTY TESTED (FOR HEAVY METALS & MIRCOBES)

NON-GMO

NO ARTIFICIAL INGREDIENTS

VEGAN

BIOAVAILABLE FORM

THIRD-PARTY TESTED (FOR HEAVY METALS & MIRCOBES)

NON-GMO

NO ARTIFICIAL INGREDIENTS

VEGAN

BIOAVAILABLE FORM

THIRD-PARTY TESTED (FOR HEAVY METALS & MIRCOBES)

NON-GMO

NO ARTIFICIAL INGREDIENTS

After 60 Days

Neupril has helped hundreds of thousands of customers focus—and follow through.

Don't just take our word for it. See for yourself what Neupril customers experience within 60 days of taking methylfolate + methyl B12.

84%

of people were more likely to start or complete a task*

100% 75% 50% 25% 0%
+79%

of people felt more ambitious and able to take on a difficult task*

day 0 day 60
100% 75% 50% 25%

Results from real customers* within 2 months

Improvement In Mood 91%
Improvement In Focus 74%
Improvement In Energy 73%
Neupril Methylfolate liquid supplement drops in an amber bottle with a precision glass dropper.

Week 1

Lift the fog, feel the difference

Methylfolate supports neurotransmitter synthesis, helping clear brain fog and calm anxious thoughts.*

Month 1

Real natural energy, not caffeine highs

Steady methylation support helps boost dopamine and serotonin for more focus, drive, and a balanced mood. Without the crash.*

Month 3

Break the burnout cycle

Consistent use supports nervous system recovery and resilience, helping you stay clear-headed, motivated, and grounded even under stress or during recovery.*

Month 6

Rebuild focus and emotional balance

Long-term use strengthens attention, mood stability, and motivation. Helping you feel more like yourself again.*

Clinically Backed Nutrients For Real, Noticeable Benefits

Pure L-Methylfolate raw ingredient powder for Neupril high-bioavailability supplements

L-5-methyltetrahydrofolate (L-5-MTHF)

KEY FUNCTION

Supports methylation and neurotransmitter production

Highly bioavailable Methylcobalamin Vitamin B12 liquid concentrate for Neupril professional-grade supplements.

Methylcobalamin (Methyl-B12)

KEY FUNCTION

Supports energy production and neurological function

L-5-methyltetrahydrofolate (L-5-MTHF)

Supports methylation and neurotransmitter production

Pure L-Methylfolate raw ingredient powder for Neupril high-bioavailability supplements

WHAT IS IT?

Methylfolate is the bioactive form of folate that directly supports neurotransmitter production, DNA synthesis, and healthy cell growth. It bypasses the conversion step many people struggle with due to MTHFR gene variants, ensuring efficient dopamine and serotonin synthesis for balanced mood, focus, and cognitive performance. It also helps regulate homocysteine, reducing oxidative stress and supporting long-term brain and cardiovascular health.

NEUPRIL DOSAGE

15mg

THE SCIENCE

Research shows that 15 mg of L-methylfolate supports cognitive, mood, and cellular health by providing the active form of folate needed for neurotransmitter production, methylation, and homocysteine regulation. Clinical studies have found that this dosage helps promote healthy serotonin and dopamine activity and may benefit individuals who have difficulty converting folic acid due to MTHFR gene variants.

Methylcobalamin (Methyl-B12)

Supports neurological function and energy production

Highly bioavailable Methylcobalamin Vitamin B12 liquid concentrate for Neupril professional-grade supplements.

WHAT IS IT?

Methyl-B12 is an essential nutrient that fuels energy production, supports neurotransmitter balance, and promotes cognitive performance. It’s crucial for dopamine and serotonin synthesis, which drive motivation, mood, and mental clarity, while also aiding red blood cell formation and mitochondrial function. Additionally, B12 helps regulate homocysteine, reducing oxidative stress and supporting long-term brain health.

NEUPRIL DOSAGE

1000mcg

OTHER BRANDS

5-400mcg on average

THE SCIENCE

Research suggests that sufficient B12 supports focus, mental endurance, and cognitive clarity, making it an essential nutrient for sustained energy, motivation, and optimal performance.

Benefits You Can See and Feel

Neupril L-Methylfolate and Methyl-B12 vitamin liquid dietary supplement bottles in a floating group shot
Icon representing sustained natural energy and vitality

Clean Energy

Gives your cells the raw material to convert food into sustained energy without the crash.

deep Sleep

Supports restful sleep by promoting healthy serotonin and melatonin production naturally.

Mood Boost

Helps your body produce serotonin and dopamine naturally to support emotional balance and well-being.

DNA & Detox

Activates your body's master regulator for gene expression, cellular repair, and toxin clearance.

Icon representing enhanced mental clarity and focus

Sharp Focus

Sharpens mental clarity and concentration by supporting the neurotransmitters your brain relies on.

Icon representing overall brain health and neurological function

Brain Health

Fuels the neurotransmitters your mind runs on for sharper thinking and lasting mental clarity.

Icon representing sustained natural energy and vitality

Clean Energy

Gives your cells the raw material to convert food into sustained energy without the crash.

deep Sleep

Supports restful sleep by promoting healthy serotonin and melatonin production naturally.

Mood Boost

Helps your body produce serotonin and dopamine naturally to support emotional balance and well-being.

Neupril L-Methylfolate and Methyl-B12 vitamin liquid dietary supplement bottles in a floating group shot

DNA & Detox

Activates your body's master regulator for gene expression, cellular repair, and toxin clearance.

Icon representing enhanced mental clarity and focus

Sharp Focus

Sharpens mental clarity and concentration by supporting the neurotransmitters your brain relies on.

Icon representing overall brain health and neurological function

Brain Health

Fuels the neurotransmitters your mind runs on for sharper thinking and lasting mental clarity.

Us vs. Them

Not overhyped or overpriced. Just pure methylfolate + methyl B12 made enjoyable and for every unique brain.

Clinical Strength

Fast Absorption

Clean Ingredients

Methyl B12 Cofactor

Delicious Taste

Neupril

Others

Tested, Trusted, and Certified

Neupril’s methylfolate is third-party tested to confirm purity, potency, and safety, ensuring every drop meets clinical standards and is free from heavy metals, microbes, and unwanted fillers.

Gluten Free

USA Made

Clinical Studies

Quality Verified

Get Your Neupril

Macro close-up of a glass dropper tip filled with red liquid L-Methylfolate supplement showing bubbles and detail against a light blue background

Join 1,000,000+ Others Filling Their Methylation Gaps

Join Others Filling Their Methylation Gaps

4.5 stars | 15K+ reviews | 1,000,000+ members

THE BEST form of the folic acid you can get and I love this brand! Worth its money and actually helped me a lot!

Chris G.

Love this brand and the effectiveness of this Methylfolate! It helps my energy, hormones, and even sleep quality. It absorbs better and faster than other brands I've had, and it tastes good!

Kylie L.

Love these supplements! Have been taking these pre pregnancy and now that I’m pregnant. I have the MTFHR gene mutation and love that these are methylated.

Lauren B.

Great product. Good quality and very effective. My 73 year old Mother and my family takes it daily. Perfect if you have a MTHFR snippet in your DNA.

Polina Y.

I felt less stressed right away. I did that cheek swab test (from my doctor & sent it in) & it showed that I had one mutation, not two, but, I see a huge difference in my anxiety levels & it's only been a week!

Matthew M.

I love this supplement! I've been taking it for the last couple weeks and have started to feel a difference in my energy levels. It's very easy to take since it's just drops. The price is very affordable for such a high quality product.

Gwen C.

    Any last questions?

    Try Neupril

    How quickly will I notice results?

    Most customers report improved focus, energy, and mood within the first few days of consistent use, with more noticeable benefits appearing after 2-4 weeks.

    Are these safe for daily use?

    Yes, Neupril Pure Methylfolate are crafted with natural, high-quality ingredients that are safe for everyday use without harsh side effects. Consult your healthcare provider if you have any specific medical concerns.

    Can I take methylfolate with other supplements or medications?

    Generally, yes. But it’s best to talk to your healthcare provider if you're other medications or supplements.

    Does body weight affect how many drops I should take?

    Not necessarily. Dosage isn’t determined by weight. it’s determined by your body’s methylation needs. Everyone processes folate differently depending on factors like genetics (such as MTHFR variants), stress levels, diet, and overall methylation efficiency. A heavier person doesn’t automatically need more drops. The recommended 10-drop dose is designed to support optimal methylation for most adults. If needed, adjustments should be made based on how you feel or under the guidance of a healthcare professional.

    What if I don't know if I have MTHFR?

    Even without the MTHFR mutation, methylfolate is still the superior form of folate. Instead of relying on conversion steps, Neupril provides the body with the active form of folate it can use immediately enhancing focus, improving mood, and boosting natural energy.

    What does Neupril taste like?

    At Neupril, our drops have a refreshing organic berry flavor that’s light, smooth, and easy to take. Whether under the tongue or mixed into a drink, most people find it pleasantly subtle. Not too sweet, not too strong. Just clean, natural berry goodness you’ll actually enjoy taking every day.